What are the side effects of Abatacept?

Scientific name: Abataip

English name: Abatacept

The common brand name of this drug in Hong Kong is: Orencia

Drug class: Immunomodulatory drugs

Drug Subclass: Biological disease-modifying antirheumatic drugs, selective T-cell costimulatory modulators

Main use: Psoriatic arthritis, moderate to severe rheumatoid arthritis, juvenile idiopathic arthritis

Common dosage forms:
– 125mg, 250mg (injection)
– 250mg (intravenous)

How does Abatacept work?
Abatacept is a selective T-cell co-stimulatory modulator and a biological disease-modifying anti-rheumatic drug. It modulates the activity of immune system cells to suppress the inflammatory response that causes arthritis and is indicated for the treatment of psoriatic arthritis, moderate to severe rheumatoid arthritis, and juvenile idiopathic arthritis.

How to use Abatacept and adjust dosage?
Abatacept is an injectable drug that can be given either subcutaneously or intravenously.

To treat psoriatic arthritis, moderate to severe rheumatoid arthritis:
Intravenous drip: Dosage should be adjusted according to body weight. After the initial injection, repeat injections are required on the 2nd and 4th weeks; thereafter every 4 weeks.
<60 kg: 500 mg
60 – 100 kg: 750 mg
100 kg: 1000 mg

Subcutaneous injection: 125 mg once a week.

To treat juvenile idiopathic arthritis:
Children and adolescents ≥ 6 years old:
Intravenous drip: Dosage should be adjusted according to body weight. After the initial injection, repeat injections are required on the 2nd and 4th weeks; thereafter every 4 weeks.
<75 kg: 10 mg/kg
75-100 kg: 750 mg
100 kg: 1000 mg

Children and adolescents ≥2 years of age:
Subcutaneous injection:
10-<25 kg: 50 mg once a week
25-<50 kg: 87.5 mg once a week
≥50 kg: 125 mg once a week

What are the side effects of Abatacept?
Common side effects of abatacept include headache, upper respiratory tract infection, nasopharyngitis, and nausea.

Who should not use Abatacept?
Those who are allergic to duabatacept or any of the ingredients in its preparations.

Pharmacist Tip:
– Store brand new syringes in the refrigerator (do not freeze).
– After taking the syringe out of the refrigerator, let it sit for 30 minutes until it reaches room temperature before use. Do not use any heating method, such as microwave or put in warm water. Also, do not remove the needle cover while waiting.
– Each syringe can only be used once.
– Use a different body part for each injection.
– This medicine may make you more susceptible to infections. If symptoms such as fever or sore throat occur, seek medical attention immediately.

Common taking time:
Abatacept is a drug that can be injected under the skin, either into your abdomen or thigh, or into your upper arm by someone else.

The information is for reference only, and the actual medication time will be adjusted according to individual circumstances.

Common possible conflicting drugs:
– Live vaccine
– TNF blockers such as Etanercept, Infliximab
– Biological disease-modifying antirheumatic drugs such as Tocilizumab, Rituximab

If you are taking the above medicines, please inform your doctor or pharmacist, the dosage may need to be adjusted.

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