How does Entresto work?

Entresto
Use: Symptomatic chronic heart failure


How does Entresto work?
Entresto is a product containing sacubitril and valsartan, which are neprilysin inhibitors and angiotensin type II receptor antagonists, respectively. Sacubitril helps to relax blood vessels and reduce sodium and fluid in the body; while valsartan inhibits vasoconstriction and the accumulation of sodium and fluid.

The combination of the two can help improve the heart’s ability to pump blood, making it suitable for treating heart failure.

How to use Entresto and adjust dosage?
Entresto is an oral medication. The usual starting dose is 100 mg twice daily; escalate to 200 mg twice daily over 2-4 weeks.

Children, patients with impaired liver or kidney function may need to take lower doses.

What are the side effects of Entresto?
Common side effects of Entresto include dizziness and cough. In rare cases, allergic reactions may occur, including symptoms such as difficulty breathing, hives, facial swelling, and swollen lips.

Who should not use Entresto:
Those who are allergic to sacubitril, valsartan, or any component of their preparations
People who have experienced angioedema after taking angiotensin-converting enzyme inhibitor (ACEi) or angiotensin type II receptor blocker (ARB) drugs
Pregnant or breastfeeding women


Pharmacist Tip:
If you see postural hypotension, you should stand slowly, or sit and rest for a while.
Do not take any potassium (Potassium) supplements during treatment.
Avoid alcohol during treatment.
Common taking time:

Entresto can be taken on an empty or full stomach and should be taken twice daily (morning and evening are recommended).


The information is for reference only, and the actual medication time will be adjusted according to individual circumstances.

Common possible conflicting drugs:

Aliskiren
Lithium
Potassium-sparing diuretics such as Spironolactone, Amiloride
Angiotensin-converting enzyme inhibitors, such as Captopril, Enalapril
NSAIDs such as Ibuprofen, Aspirin


If you are taking the above medicines, please inform your doctor or pharmacist, the dosage may need to be adjusted.

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